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Updated: May 13, 2026
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[Pathologically confirmed histoplasmosis: analysis of 14 cases]
1Department of Respiratory Diseases, Southern Medical University, Guangzhou, China.
Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University
|February 28, 2013
Summary
Histoplasmosis presents with varied symptoms and can be misdiagnosed due to non-specific imaging. Definitive diagnosis of this fungal infection relies on pathological examination, with most patients responding well to antifungal treatment.
Area of Science:
- Infectious Diseases
- Mycology
- Pathology
Context:
- Histoplasmosis is a fungal infection with diverse clinical presentations.
- Diagnosis can be challenging due to non-specific symptoms and imaging findings.
- Retrospective analysis of 14 biopsy-confirmed cases from 2000-2012.
Purpose:
- To summarize the clinical features, diagnosis, treatment, and outcomes of histoplasmosis.
- To highlight diagnostic challenges and the importance of pathological confirmation.
Summary:
- Clinical manifestations included fever, cough, chest and abdominal pain, with some patients exhibiting neurological symptoms or lymphadenopathy.
- Seven patients had underlying immunosuppression; nine showed chest imaging abnormalities.
- Initial misdiagnoses included tuberculosis and malignancy.
- Antifungal treatments (itraconazole, amphotericin B, fluconazole, voriconazole) were effective in 90% of treated patients.
Impact:
- Emphasizes the need for high clinical suspicion for histoplasmosis, especially in immunocompromised individuals.
- Underscores the critical role of pathological examination for accurate diagnosis.
- Provides insights into effective antifungal treatment strategies for histoplasmosis.
