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FOX(M1) news--it is cancer
Marianna Halasi1, Andrei L Gartel
1University of Illinois at Chicago, Department of Medicine, Chicago, IL 60612, USA.
Molecular Cancer Therapeutics
|February 28, 2013
Summary
Forkhead box M1 (FOXM1) is a key transcription factor driving cell proliferation and cancer development. This review details FOXM1
Area of Science:
- Molecular Biology
- Oncology
- Cell Biology
Background:
- Forkhead box M1 (FOXM1) is a transcription factor crucial for cell proliferation and cell-cycle progression.
- FOXM1 expression is elevated in proliferating and malignant cells, and its overexpression is observed in over 20 human cancers.
- Despite regulation by tumor suppressors like RB, p53, and p19(ARF), FOXM1 remains active in most human cancers.
Purpose of the Study:
- To review and discuss the contribution of FOXM1 to the hallmarks of cancer.
- To summarize the diverse cellular processes influenced by FOXM1 in tumorigenesis.
Main Methods:
- Literature review synthesizing experimental data on FOXM1's role in cancer.
- Analysis of FOXM1's transcriptional targets involved in cancer development.
Main Results:
- FOXM1's oncogenic potential stems from its ability to activate genes critical for cancer development.
- FOXM1 contributes to multiple facets of cancer progression, aligning with established hallmarks of cancer.
Conclusions:
- FOXM1 is a significant oncogenic driver with a broad impact on cancer development.
- Understanding FOXM1's role is crucial for developing targeted cancer therapies.
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