Related Experiment Video

Updated: May 13, 2026

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve
07:34

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Published on: August 5, 2021

Valve disease in chronic venous disorders: a quantitative ultrastructural analysis by transmission electron

Wolfgang G Mouton1, Anna K Habegger, Beat Haenni

  • 1Department of Surgery, Spital STS AG Thun, Switzerland. wolfgang.mouton@spitalstsag.ch

Swiss Medical Weekly
|February 28, 2013
PubMed

Insights

Chronic venous disease shows increased elastin in valves and more endothelial damage as severity progresses. This study investigated venous valve and wall ultrastructure in relation to disease severity.

Area of Science:

  • Vascular Biology
  • Histopathology
  • Biomaterials Science

Background:

  • Chronic venous disease (CVD) affects venous valves and walls.
  • Understanding ultrastructural changes is crucial for CVD management.

Purpose of the Study:

  • To investigate the ultrastructure of venous valves and walls in patients with varying stages of chronic venous disease.
  • To correlate changes in elastin and collagen content and endothelial integrity with CVD severity.

Main Methods:

  • Patients were grouped based on the CEAP classification (C1-C6).
  • Great saphenous vein valves and adjacent walls were harvested.
  • Transmission electron microscopy and stereology were used to assess elastin, collagen, and endothelial surface.

Main Results:

  • Elastin and collagen content per unit surface area increased with CVD severity (C1 < C2/C3 < C4-C6).
  • A trend towards increased endothelial damage was observed on both valve and vessel walls with disease progression.

Conclusions:

  • Venous valve elastin content appears to increase morphologically with CVD progression.
  • Endothelial damage in venous valves and walls tends to worsen as chronic venous disease advances.
Abstract

More Related Videos

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane08:05

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens06:02

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens

Published on: April 18, 2013

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
Varicose Veins I: Introduction01:26

Varicose Veins I: Introduction

Varicose veins, or varicosities, are abnormally dilated and twisted superficial veins caused by venous valve incompetence. This condition commonly affects the lower extremities, especially the saphenous veins, due to the higher pressure from prolonged standing and walking. However, varicosities can also occur in other areas, such as the esophagus, vulva, spermatic cords, and anorectal region.Etiology and typesPrimary varicose veins, often idiopathic, are more common in women due to inherent...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...