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Updated: May 13, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Zoom Zoom: racing CARs for multiple myeloma
1Translational Research Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. mausm@uphs.upenn.edu
Abstract:
Chimeric antigen receptors redirect T cells to surface antigens. Discovery and validation of appropriate target antigens expand the possible indications for chimeric-antigen receptor (CAR)-T cells. B-cell maturation antigen (BCMA) is expressed only on mature B cells and plasma cells and promotes their survival. BCMA is a promising target for CAR-T cells in multiple myeloma.
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