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Updated: May 13, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
[Thirty years after the Cuban dengue hemorrhagic epidemic occurred in 1981]
1Instituto de Medicina Tropical Pedro Kouri, La Habana, Cuba. lupe@ipk.sld.cu
Insights
Cuba has controlled dengue hemorrhagic fever since its 1981 epidemic through sustained surveillance and research. Despite occasional outbreaks, the country has maintained its dengue-free status for over 30 years.
Area of Science:
- Tropical medicine
- Epidemiology
- Infectious disease surveillance
Context:
- Cuba experienced a severe dengue hemorrhagic fever epidemic in 1981, reporting over 344,000 cases.
- This epidemic resulted in significant morbidity and mortality, with 10,312 severe cases and 158 fatalities.
- The 1981 epidemic underscored the urgent need for robust public health interventions and research.
Purpose:
- To summarize key aspects of the 1981 dengue hemorrhagic fever epidemic in Cuba.
- To highlight the country's laboratory surveillance strategies for dengue.
- To present findings from significant research conducted on dengue in Cuba.
Summary:
- Cuba has successfully maintained a dengue-free status for over three decades post-1981 epidemic.
- Sustained surveillance, control measures, and research have been crucial in managing subsequent dengue outbreaks.
- The paper reviews historical epidemic data, laboratory surveillance, and major research outcomes.
Impact:
- Demonstrates the long-term success of integrated public health strategies in combating vector-borne diseases.
- Provides insights into effective dengue surveillance and control applicable to other tropical regions.
- Contributes to the understanding of dengue epidemiology and management in endemic areas.
Abstract:
Cuba reported the first dengue hemorrhagic fever epidemic in the American region in 1981. More than 344 203 cases with 10 312 severe and very severe cases and 158 fatalities were reported. Thirty years after this epidemic, the established surveillance, the control actions and the performed research studies have allowed the country to keep free of dengue, although some epidemics and waves of transmission have occurred, which have finally been eliminated. This paper summarized some interesting aspects related with this epidemic as well as with the laboratory surveillance and results of some of the main research works.
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