Related Experiment Video
Updated: May 13, 2026

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve
Published on: August 5, 2021
Mechanics of healthy and functionally diseased mitral valves: a critical review
Jean-Pierre M Rabbah1, Neelakantan Saikrishnan, Andrew W Siefert
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Abstract:
The mitral valve is a complex apparatus with multiple constituents that work cohesively to ensure unidirectional flow between the left atrium and ventricle. Disruption to any or all of the components-the annulus, leaflets, chordae, and papillary muscles-can lead to backflow of blood, or regurgitation, into the left atrium, which deleteriously effects patient health. Through the years, a myriad of surgical repairs have been proposed; however, a careful appreciation for the underlying structural mechanics can help optimize long-term repair durability and inform medical device design. In this review, we aim to present the experimental methods and significant results that have shaped the current understanding of mitral valve mechanics. Data will be presented for all components of the mitral valve apparatus in control, pathological, and repaired conditions from human, animal, and in vitro studies. Finally, current strategies of patient specific and noninvasive surgical planning will be critically outlined.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Regurgitation I: Introduction
Mitral Stenosis I: Introduction
Mitral Regurgitation II: Clinical Features and Diagnostic Tests
Mitral Regurgitation III: Medical Management
Mitral Valve Prolapse II: Assessment and Management
