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Related Experiment Video

Updated: May 13, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

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Published on: June 18, 2018

Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients.

Juan-Carlos Bustamante1, Alfonso Barrós-Loscertales, Víctor Costumero

  • 1Department of Basic Psychology, Clinical Psychology and Psychobiology, Universitat Jaume I, Spain.

Addiction Biology
|March 1, 2013
PubMed
Summary

Long-term cocaine addiction alters striatal brain activity. Treatment duration and abstinence length positively modulated brain responses to non-drug rewards in abstinent cocaine-dependent patients.

Keywords:
AbstinenceaddictioncocainefMRIrewardstriatum

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Area of Science:

  • Neuroscience
  • Addiction Research
  • Neuroimaging

Background:

  • Cocaine addiction is linked to disruptions in the brain's reward system, particularly the striatum.
  • Understanding these alterations is crucial for developing effective addiction treatments.

Purpose of the Study:

  • To investigate striatal functional alterations in long-term abstinent cocaine-dependent patients.
  • To examine how treatment duration and abstinence length affect brain activity in response to non-drug rewards.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used during a Monetary Incentive Delay task.
  • Region of interest analyses focused on the dorsal and ventral striatum.
  • Regression analyses explored correlations between brain activity and treatment/abstinence parameters.

Main Results:

  • Cocaine-dependent patients showed reduced activation in the right caudate during reward anticipation compared to controls.
  • Increased treatment duration correlated with higher left caudate activation during reward anticipation.
  • Longer abstinence length negatively correlated with nucleus accumbens activation during reward processing.

Conclusions:

  • The caudate and nucleus accumbens exhibit distinct response patterns to non-drug rewards in cocaine addiction.
  • Treatment success, indicated by duration and abstinence length, can modulate these brain responses.