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The role of critical shear stress on acute coronary syndrome

Jongyoun Kim1, Hyemoon Chung, Minhee Cho

  • 1Department of Internal Medicine, Yonsei University Medical College, Seoul, Korea.

Clinical Hemorheology and Microcirculation
|March 1, 2013
PubMed

Insights

Critical shear-stress (CSS), a measure of red blood cell aggregation, is significantly higher in acute coronary syndrome (ACS) patients. This finding suggests CSS may serve as a novel risk marker for ACS.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biophysics

Background:

  • Red blood cell (RBC) aggregation is linked to vascular diseases like acute coronary syndrome (ACS).
  • Critical shear-stress (CSS) quantifies the shear stress needed to disperse RBC aggregates.

Purpose of the Study:

  • To assess the role of CSS in ACS compared to stable angina (SA).
  • To evaluate the correlation between CSS and atherosclerosis biomarkers (fibrinogen, hs-CRP).

Main Methods:

  • Simultaneous measurement of shear stress and light backscattering using a microfluidic hemorheometer.
  • Analysis of 169 SA patients and 223 ACS patients, including medical history and laboratory data.

Main Results:

  • ACS patients exhibited higher white blood cell counts, hs-CRP, and whole blood viscosities.
  • CSS was 25.7% higher in ACS patients (333.8 ± 147.8 mPa) than in SA patients (265.4 ± 149.9 mPa) (p < 0.001).
  • CSS showed strong correlations with fibrinogen and erythrocyte sedimentation rate (ESR).

Conclusions:

  • Elevated CSS is associated with ACS.
  • CSS may function as a novel risk marker for acute coronary syndrome.

Keywords:
Critical shear stressRBC aggregationacute coronary syndrome

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