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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Chronic Pancreatitis II: Pathophysiology

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Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...

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Related Experiment Videos

[Chronic recurrent multifocal osteomyelitis with interstitial myositis].

Saori Nagashima1, Tomo Nozawa, Toshitaka Kizawa

  • 1Department of Pediatrics Yokohama City University School of Medicine.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|March 1, 2013
PubMed
Summary

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare inflammatory bone disorder. This case highlights CRMO presenting with unusual interstitial myositis, successfully treated with NSAIDs and bisphosphonate.

Related Experiment Videos

Area of Science:

  • Pediatric Rheumatology
  • Musculoskeletal Disorders
  • Inflammatory Diseases

Background:

  • Chronic recurrent multifocal osteomyelitis (CRMO) is a sterile osteomyelitis primarily affecting children.
  • CRMO diagnosis can be challenging due to its varied presentations.
  • Co-occurrence of CRMO with other inflammatory conditions is rarely reported.

Observation:

  • An 11-year-old boy presented with fever, leg pain, and foot swelling, initially suspected as polymyositis based on MRI.
  • Subsequent development of clavicular swelling led to osteomyelitis diagnosis via bone biopsy.
  • Whole-body FDG-PET/CT revealed multifocal bone lesions and muscle uptake, confirming CRMO with associated interstitial myositis.

Findings:

  • The patient was diagnosed with CRMO and interstitial myositis, a rare co-occurrence.
  • Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) and bisphosphonate resulted in significant clinical improvement.
  • Negative bacterial cultures from bone biopsy confirmed the non-infectious nature of the osteomyelitis.

Implications:

  • This case expands the clinical spectrum of CRMO, emphasizing its potential association with interstitial myositis.
  • Early diagnosis and appropriate management, including NSAIDs and bisphosphonates, are crucial for favorable outcomes in CRMO.
  • Further research is warranted to understand the pathophysiology and management of CRMO associated with myositis.