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Updated: May 13, 2026
Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Is exercise-induced muscle damage susceptibility body segment dependent? Evidence for whole body susceptibility
M Machado1, L E Brown, P Augusto-Silva
1Laboratory of Human Movement Studies - Universitary Fundation of Itaperuna - Itaperuna, RJ, Brazil. marcomachado1@gmail.com
Objective:
The current study examined serum CK activity following bench press (BP) and leg press (LP) exercise-induced muscle damage to evaluate agreement of subjects classification as either high (HiR) or normal responders (NoR) between upper and lower body muscle groups.
Methods:
Forty-two men performed two resistance exercise bouts (BP and LP) of four sets of maximum repetitions to concentric failure at 10RM, following a random design.
Results:
Fourteen subjects were classified as HiR after the BP and thirteen subjects after LP, while nine subjects were classified as HiR for both exercises. The analysis revealed good agreement (Kappa=0.528, with SE=0.137 and 95% confidence interval: from 0.259 to 0.798). Additionally, we found a significant moderate correlation (r=0.65, p<0.001) between CK peaks obtained following LP and BP.
Conclusion:
Our results suggest that exercise-induced muscle damage susceptibility is a whole body characteristic and is not body segment dependent. Thus, it may be that genetic or systemic mechanisms explain individual variation in muscle damage susceptibility.
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