Related Experiment Video

Updated: May 13, 2026

Blind Endotracheal Intubation in Neonatal Rabbits
04:04

Blind Endotracheal Intubation in Neonatal Rabbits

Published on: February 26, 2021

The neonatal intubation causes defects in primary teeth of premature infants

Norma Suely Falcao de Oliveira Melo1, Regina Paula Guimaraes Vieira Cavalcante da Silva, Antonio Adilson Soares de Lima

  • 1Department of Stomatology, School of Dentistry, Universidade Federal do Parana - UFPR, Curitiba-PR, Brazil.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|March 1, 2013
PubMed

Insights

Neonatal tracheal intubation significantly increases the risk of enamel defects in primary teeth of preterm infants. Longer intubation duration correlates with a higher probability of developing these dental enamel defects.

Area of Science:

  • Neonatal care
  • Pediatric dentistry
  • Developmental biology

Background:

  • Preterm infants are vulnerable to various health complications.
  • Neonatal intubation is a common procedure for respiratory support in preterm infants.
  • Enamel defects can have long-term implications for oral health.

Purpose of the Study:

  • To investigate the association between neonatal intubation and enamel defects in primary teeth.
  • To determine if intubation duration and gestational age influence enamel defect occurrence.
  • To identify specific tooth regions affected by enamel hypoplasia in intubated preterm infants.

Main Methods:

  • Observational, prospective, analytical study with convenience sampling.
  • Clinical examination of oral cavities in 157 preterm infants.
  • Analysis of intubation duration, gestational age, and enamel defect prevalence.

Main Results:

  • 86.3% of intubated children exhibited enamel defects, compared to 13.7% of non-intubated children.
  • Enamel defects showed an inverse relationship with gestational age.
  • Intubation duration was directly proportional to the probability of developing enamel defects (DDE).

Conclusions:

  • Neonatal tracheal intubation is a primary cause of enamel defects in preterm infants' primary teeth.
  • Extended intubation periods increase the likelihood of dental enamel defects.
  • Hypoplasia predominantly affects the upper incisors (central and lateral) on the left side, correlating with laryngoscope manipulation.
Abstract

More Related Videos

Non-Nutritive Suck Parameters Measurements Using a Custom Pressure Transducer System06:19

Non-Nutritive Suck Parameters Measurements Using a Custom Pressure Transducer System

Published on: April 19, 2024

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices08:01

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices

Published on: August 14, 2015

Related Concept Videos

Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Endotracheal Intubation I: Procedure01:15

Endotracheal Intubation I: Procedure

Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...