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Updated: May 13, 2026
13:08
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
Factor V Leiden mutation-related chronic skin ulcers
Kadir Kayatas1, Filiz Cebeci, Cumali Karatoprak
1Haydarpasa Numune Training and Research Hospital, Üsküdar, Istanbul, Turkey.
The International Journal of Lower Extremity Wounds
|March 1, 2013
Summary
A rare inherited hypercoagulable state, factor V Leiden mutation, caused chronic, nonhealing skin ulcers in a young woman. Anticoagulant therapy successfully healed the ulcers, preventing recurrence.
Area of Science:
- Dermatology
- Hematology
- Genetics
Background:
- Chronic skin ulcers present diagnostic challenges, often requiring extensive differential diagnosis.
- Rarely, hypercoagulable states can manifest as persistent, nonhealing skin ulcers.
- Identifying the underlying cause is crucial for effective treatment and preventing recurrence.
Observation:
- A 27-year-old woman presented with an 8-year history of recurrent, nonhealing skin ulcers.
- Previous treatments under various diagnoses at different clinics were unsuccessful.
- Skin biopsy revealed occlusive vasculopathy, prompting further investigation.
Findings:
- Genetic analysis identified a heterozygous factor V Leiden mutation, indicating an inherited hypercoagulable state.
- The patient's condition was attributed to this underlying thrombophilia.
- Treatment with anticoagulants and hyperbaric oxygen was initiated.
Implications:
- This case highlights the importance of considering hypercoagulable states in the differential diagnosis of chronic skin ulcers.
- Early identification and management of factor V Leiden mutation can lead to successful treatment outcomes.
- Effective management prevents ulcer recurrence and improves patient quality of life.
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