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Updated: May 13, 2026
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Serum uric acid and outcome after acute ischemic stroke: PREMIER study
Erwin Chiquete1, José L Ruiz-Sandoval, Luis M Murillo-Bonilla
1Department of Neurology and Psychiatry, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Cerebrovascular Diseases (Basel, Switzerland)
|March 1, 2013
Summary
Low serum uric acid (SUA) levels are linked to better short-term recovery after acute ischemic stroke (AIS). However, SUA does not predict long-term stroke outcomes, suggesting it reflects stroke severity rather than prognosis.
Area of Science:
- Neurology
- Biochemistry
- Clinical Medicine
Background:
- Serum uric acid (SUA) is a potent antioxidant with elevated levels post-acute ischemic stroke (AIS).
- The prognostic value of SUA in AIS remains unclear despite its rapid increase after stroke.
Purpose of the Study:
- To investigate the prognostic significance of serum uric acid (SUA) levels in patients with acute ischemic stroke (AIS).
Main Methods:
- A cohort of 463 AIS patients from the PREMIER registry were analyzed.
- Multivariate models assessed the association between SUA and functional outcomes (modified Rankin Scale) at various follow-up points.
- A modified Rankin Scale score of 0-1 was defined as a very good outcome.
Main Results:
- Patients with lower SUA levels (≤4.5 mg/dl) showed a significantly higher rate of very good 30-day outcomes (30.5% vs. 18.9%).
- This association between low SUA and very good short-term outcome persisted after adjusting for multiple clinical factors (OR: 1.76, 95% CI: 1.05-2.95).
- SUA levels were not associated with mortality or functional dependence at 30 days or any outcome at longer follow-up intervals (3, 6, 12 months).
Conclusions:
- Low serum uric acid concentration is modestly associated with very good short-term outcomes following acute ischemic stroke.
- Findings suggest SUA may serve as a marker for the magnitude of cerebral infarction rather than an independent predictor of long-term stroke prognosis.
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