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Related Concept Videos

Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and case-control studies.
Diabetes Mellitus: Introduction01:26

Diabetes Mellitus: Introduction

Diabetes mellitus consists of chronic metabolic disorders characterized by persistent hyperglycemia. This elevated blood glucose results from defects in insulin secretion, impaired insulin action, or both. Insulin, produced by pancreatic β-cells, is essential for maintaining glucose homeostasis by facilitating cellular glucose uptake for energy or storage. Disruptions in insulin production or function lead to glucose accumulation in the bloodstream, causing the clinical features and long-term...
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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Related Experiment Video

Updated: May 13, 2026

Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway
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Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway

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Japan Diabetic Nephropathy Cohort Study: study design, methods, and implementation.

Kengo Furuichi1, Miho Shimizu, Tadashi Toyama

  • 1Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan.

Clinical and Experimental Nephrology
|March 1, 2013
PubMed
Summary

This study establishes the Japan Diabetic Nephropathy Cohort Study (JDNCS) to collect data on diabetic nephropathy in Japan. Future analysis will offer insights into patient outcomes and disease progression.

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Last Updated: May 13, 2026

Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway
08:15

Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway

Published on: May 10, 2024

Area of Science:

  • Nephrology
  • Endocrinology
  • Epidemiology

Background:

  • Diabetic nephropathy significantly impacts public health and the economy.
  • There is a lack of national registries for diabetic nephropathy in Japan.
  • This study aims to improve clinical staging and develop early diagnostic markers.

Purpose of the Study:

  • To establish a prospective cohort for diabetic nephropathy in Japan.
  • To collect clinical data and urine samples for research.
  • To revise clinical staging and develop new diagnostic markers for early detection.

Main Methods:

  • A nationwide, web-based, prospective registry system was established by the Japanese Society of Nephrology.
  • The system includes the Japan Renal Biopsy Registry (JRBR) and Japan Kidney Disease Registry (JKDR).
  • The Japan Diabetic Nephropathy Cohort Study (JDNCS) was created to collect physical and laboratory data.

Main Results:

  • Data from 321 JDNCS participants (average age 65) were analyzed.
  • Participants showed varied presentations, including preserved eGFR with low albuminuria or low eGFR with advanced proteinuria.
  • Compared to JRBR and JKDR, JDNCS patients had lower proteinuria with moderately preserved eGFR.

Conclusions:

  • National registries for evaluating diabetic nephropathy prognosis are scarce in Japan.
  • The JDNCS cohort will provide valuable data for future research.
  • Analysis of JDNCS data will yield insights into the epidemiology and outcomes of type 2 diabetes in Japan.