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Updated: May 13, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Conjugal giant cell arteritis.

Meng Chen¹, Rachel Gelman, Nagham Al-Zubidi

¹Baylor College of Medicine, Houston, Texas, USA.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society

|March 1, 2013

Summary

This summary is machine-generated.

Giant cell arteritis (GCA) pathogenesis is complex. This study documents GCA in a married couple from the US Gulf Coast, expanding the known geographic distribution of this rare familial occurrence.

Related Experiment Videos

Last Updated: May 13, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

Rheumatology
Immunology
Epidemiology

Background:

Giant cell arteritis (GCA) is an inflammatory vasculitis with unclear pathogenesis.
Potential contributing factors include genetic, environmental, and immune system components.
Previous reports of conjugal GCA are limited to Northern Europe and the Northern United States.

Observation:

This report details a rare case of GCA occurring in a husband and wife.
The couple resides in the southern Gulf Coast region of the United States.
This represents a geographically distinct occurrence of familial GCA.

Findings:

The occurrence of GCA in a conjugal pair from the US Gulf Coast expands the known geographic distribution of this phenomenon.
This case contributes to the understanding of potential environmental or genetic factors in GCA pathogenesis.
Further research into familial GCA patterns is warranted.

Implications:

The findings suggest that GCA may occur in conjugal pairs in diverse geographic locations.
This case highlights the need to consider familial aggregation in GCA etiology.
Understanding the pathogenesis of GCA may benefit from studying familial and geographically diverse cases.