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Related Concept Videos

Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...

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Related Experiment Video

Updated: May 13, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
09:22

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis

Published on: May 12, 2020

Kingella kingae keratitis.

María-Carmen Muñoz-Egea1, María García-Pedrazuela, Iris González-Pallarés

  • 1Department of Clinical Microbiology, IIS-Fundación Jiménez Díaz, Madrid, Spain. mcmunozegea@fjd.es

Journal of Clinical Microbiology
|March 1, 2013
PubMed
Summary
This summary is machine-generated.

This study reports the first adult cases of Kingella kingae keratitis, a rare eye infection. Prompt identification using mass spectrometry aided treatment in one patient.

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Last Updated: May 13, 2026

Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
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Published on: May 12, 2020

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Microbiology

Background:

  • Kingella kingae is an uncommon cause of human infection, particularly in adults.
  • Ocular infections caused by Kingella kingae are exceedingly rare.
  • Accurate and rapid identification of microbial pathogens is crucial for effective treatment.

Observation:

  • Two adult patients presented with keratitis (corneal inflammation/infection).
  • Kingella kingae was identified as the causative agent in both cases.
  • Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) facilitated species identification.

Findings:

  • One patient achieved an uneventful recovery with topical antimicrobial therapy.
  • The outcome for the second patient could not be confirmed due to loss to follow-up.

Implications:

  • This highlights Kingella kingae as a potential, albeit rare, cause of keratitis in adult populations.
  • MALDI-TOF MS is a valuable tool for identifying unusual pathogens in ophthalmic infections.
  • Further research may be warranted to understand the epidemiology and optimal management of Kingella kingae ocular infections.