Related Experiment Video
Updated: May 13, 2026
04:37
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
Published on: May 23, 2025
Platelet activation: a link between psoriasis per se and subclinical atherosclerosis--a case-control study
H M A Saleh1, E A S Attia, A M Onsy
1Department of Dermatology, Venereology and Andrology, Ain Shams University, Cairo, Egypt.
The British Journal of Dermatology
|March 2, 2013
Summary
Psoriasis patients, especially those with moderate to severe disease, show increased platelet CD62 expression, indicating a higher risk of atherosclerosis. This finding highlights CD62 as a potential biomarker for assessing cardiovascular risk in psoriasis.
Area of Science:
- Cardiovascular Medicine
- Dermatology
- Hematology
Background:
- Psoriasis and atherosclerosis share potential pathomechanisms involving platelet activation.
- Activated platelets exhibit elevated P-selectin (CD62) expression and increased mean platelet volume (MPV).
- Impaired brachial artery flow-mediated dilatation (FMD) is associated with atherosclerosis.
Purpose of the Study:
- To investigate subclinical atherosclerosis in psoriasis patients without traditional cardiovascular risk factors.
- To compare atherosclerosis markers in psoriasis patients versus healthy controls.
Main Methods:
- A case-control study involving 25 psoriasis patients and 25 matched healthy controls.
- Assessment included mean platelet volume (MPV), CD62 expression via flow cytometry, brachial artery FMD, and transthoracic echocardiography.
- Cardiac ultrasound was used for imaging.
Main Results:
- Significantly higher CD62 expression in psoriasis patients compared to controls (P < 0.001).
- Moderate/severe psoriasis cases showed higher CD62 expression than mild cases or controls.
- CD62 expression correlated positively with Psoriasis Area and Severity Index (PASI) score and baseline brachial artery diameter, but not FMD or aortic root diameter (ARD).
- ARD was significantly higher in moderate/severe psoriasis patients.
Conclusions:
- Increased platelet CD62 expression in psoriasis patients suggests elevated atherosclerosis risk, particularly in moderate/severe disease.
- CD62 expression positively correlates with ARD and PASI score, with PASI being the primary factor influencing CD62.
- MPV and FMD were not supported as diagnostic markers for subclinical atherosclerosis in psoriasis.
Related Concept Videos
01:30Peripheral Artery Disease I: Introduction
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
01:30Atherosclerosis I: Introduction
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
01:26Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
01:22Formation of the Platelet Plug
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:27Psychoneuroimmunology: Cardiovascular Disease
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
01:26Atherosclerosis III: Management
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...