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Related Experiment Video

Updated: May 13, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
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Iron accumulation in multiple sclerosis: an early pathogenic event.

Steven M LeVine1, Mehmet Bilgen, Sharon G Lynch

  • 1Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA. slevine@kumc.edu.

Expert Review of Neurotherapeutics
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Summary

Iron accumulation in the brain is detectable early in multiple sclerosis (MS), even in clinically isolated syndrome (CIS). This early iron deposition in deep gray matter suggests it

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Area of Science:

  • Neuroimaging
  • Neurology
  • Biochemistry

Background:

  • Iron accumulation in deep gray matter is observed in multiple sclerosis (MS).
  • Early detection of iron deposition in clinically isolated syndrome (CIS), an early MS stage, remains unclear.

Purpose of the Study:

  • To assess early iron deposition in the brain of patients with CIS.
  • To investigate the presence of iron accumulation in deep gray matter structures during the early stages of MS.

Main Methods:

  • Utilized 7 Tesla (7 T) MRI scanning.
  • Employed susceptibility mapping techniques.
  • Compared iron deposition in CIS patients versus healthy controls.

Main Results:

  • Increased susceptibility, indicative of iron deposition, was found in the globus pallidus, caudate, putamen, and pulvinar.
  • These findings were observed in CIS patients compared to control subjects.

Conclusions:

  • Iron deposition is an early pathological change in the development of multiple sclerosis.
  • Further research is needed to understand the mechanisms and role of iron accumulation in MS pathogenesis.