Related Experiment Video

Updated: May 13, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

Diagnostic difficulties, therapeutic strategies, and performance of scoring systems in patients with autoimmune

Cumali Efe1, Staffan Wahlin, Ersan Ozaslan

  • 1Department of Gastroenterology, Hacettepe University, Ankara, Turkey. drcumi21@hotmail.com

Scandinavian Journal of Gastroenterology
|March 2, 2013
PubMed

Insights

Diagnosing autoimmune hepatitis (AIH) with chronic viral hepatitis (HBV or HCV) is challenging. A combination of factors, not just scoring systems, is crucial for accurate AIH diagnosis in these complex cases.

Area of Science:

  • Hepatology
  • Immunology
  • Infectious Diseases

Background:

  • Diagnosing autoimmune hepatitis (AIH) is complex.
  • Concurrent AIH with chronic viral hepatitis B (HBV) or hepatitis C (HCV) presents significant diagnostic challenges.
  • Limited case studies exist on this dual diagnosis.

Purpose of the Study:

  • To retrospectively evaluate diagnostic difficulties.
  • To assess therapeutic strategies.
  • To determine the performance of scoring systems in patients with concurrent AIH and chronic viral hepatitis.

Main Methods:

  • Retrospective evaluation of 25 patients from multiple countries.
  • Application of International Autoimmune Hepatitis Group revised and simplified criteria.
  • Data collected from medical records.

Main Results:

  • 80% of patients had concurrent HCV, 20% had HBV.
  • Revised scoring system identified 72% as "probable" AIH; simplified criteria identified 48%.
  • No patients met criteria for "definite" AIH using either system.

Conclusions:

  • This study presents a significant case series of concurrent AIH and chronic viral hepatitis.
  • The revised AIH scoring system outperformed the simplified version but neither is optimal alone.
  • A definitive AIH diagnosis requires integrating serological profiles, histology, scoring systems, and treatment response.
Abstract

More Related Videos

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target11:34

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...