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Updated: May 13, 2026
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A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Targeted radiosensitization in prostate cancer
Veerander P S Ghotra1, Albert A Geldof, Erik H J Danen
1Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, The Netherlands. ghotravps@lacdr.leidenuniv.nl
Current Pharmaceutical Design
|March 2, 2013
Summary
Prostate cancer cells can resist radiotherapy, limiting treatment effectiveness. This review explores molecular targets like the apoptotic pathway, DNA damage response, and NF-κB signaling to improve radiotherapy outcomes.
Area of Science:
- Oncology
- Radiation Oncology
- Molecular Biology
Background:
- Radiotherapy is a primary treatment for advanced prostate cancer.
- Prostate cancer cell radioresistance presents a significant clinical challenge.
- Understanding radioresistance mechanisms is crucial for enhancing therapeutic strategies.
Purpose of the Study:
- To provide biological insights into key processes driving prostate cancer radioresistance.
- To focus on the apoptotic pathway, DNA damage response, and NF-κB signaling.
- To explore the potential of combining radiotherapy with targeted agents.
Main Methods:
- Review of published research findings on prostate cancer radioresistance.
- Integration of molecular mechanisms, preclinical data, and clinical applications.
- Analysis of specific signaling pathways involved in treatment resistance.
Main Results:
- Detailed examination of the apoptotic pathway's role in radioresistance.
- Explanation of DNA damage response mechanisms in prostate cancer cells.
- Elucidation of the NF-κB signaling pathway's contribution to radioresistance.
Conclusions:
- Targeting the apoptotic pathway, DNA damage response, and NF-κB signaling may overcome radioresistance.
- Combining radiotherapy with molecular targeted agents shows promise for improved prostate cancer treatment.
- Further research into these molecular targets can optimize therapeutic interventions.
