Mitochondrial dysfunction and oxidative stress in insulin resistance
Milagros Rocha1, Susana Rovira-Llopis, Celia Bañuls
1University Hospital Doctor Peset, Endocrinology Service, Avda Gaspar Aguilar 90, 46017, Valencia, Spain.
Abstract:
Evidence is mounting of the involvement of mitochondrial dysfunction in insulin resistance, diabetes and associated complications. This review aims to provide an overview of the effects of insulin resistance on mitochondrial function in several tissues. We consider the pathogenesis of insulin resistance from a mitochondrial perspective and contemplate potential beneficial effects of strategies aimed at modulating mitochondrial function in insulin resistance, including insulin and insulin-sensitizing drugs, antioxidants, and selectively targeting antioxidants to mitochondria.
Related Concept Videos
Type II Diabetes II: Pathophysiology
Type II Diabetes I: Introduction
Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...
Type I Diabetes II: Pathophysiology
Diabetes Mellitus: Introduction
Insulin: The Receptor and Signaling Pathways


