Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anaphylactic shock induced by paracetamol.

L Van Diem1, J P Grilliat

  • 1Department D of Internal Medicine and Allergy, University Hospital of Brabois, Vandoeuvre-les-Nancy, France.

European Journal of Clinical Pharmacology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The candidacy and reception of Nancy].

Histoire des sciences medicales·2001
Same author

Expiratory capnography in asthma: evaluation of various shape indices.

The European respiratory journal·1994
Same author

[Expiratory capnography in asthma. Perspectives in the use and monitoring in children].

Revue des maladies respiratoires·1992
Same author

[Serum sickness after in vitro fertilization].

Presse medicale (Paris, France : 1983)·1990
Same author

[Radiographic aspects of maxillary sinuses in asthmatic patients. Report of 100 cases].

La Revue de medecine interne·1989
Same author

Comparative evaluation of RAST and FAST for 11 allergens in 288 patients.

Allergy·1989
Same journal

Efficacy and safety of Ensitrelvir in COVID-19 patients: a systematic review and meta-analysis with focus on viral clearance and RNA change.

European journal of clinical pharmacology·2026
Same journal

Comparing National Health Technology Assessment approaches and the new European Joint Clinical Assessment framework: The case of onco-hematological medicines.

European journal of clinical pharmacology·2026
Same journal

The efficacy of letrozole in the medical management of ectopic pregnancy: a systematic review and meta-analysis.

European journal of clinical pharmacology·2026
Same journal

Detection of intravenous drug physicochemical incompatibilities in clinical practice: e-Harvis compared to reference tools.

European journal of clinical pharmacology·2026
Same journal

Efficacy and safety of doravirine/islatravir for the treatment of HIV-1: a systematic review and meta-analysis of randomized controlled trials with GRADE assessment.

European journal of clinical pharmacology·2026
Same journal

Critical analysis of digitalis glycosides: declining use but increasing poison-center exposure cases for digitoxin.

European journal of clinical pharmacology·2026
See all related articles

Adverse reactions to paracetamol in a 46-year-old woman were dose-dependent, causing severe symptoms. Histamine levels increased, indicating an allergic response to the common pain reliever.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Allergy and Immunology

Background:

  • Paracetamol (acetaminophen) is a widely used analgesic and antipyretic.
  • Adverse drug reactions can range from mild to severe, impacting patient safety.
  • Understanding the mechanisms of drug-induced hypersensitivity is crucial for clinical practice.

Observation:

  • A 46-year-old female patient experienced adverse reactions following paracetamol administration.
  • Oral challenge tests confirmed a dose-dependent relationship between paracetamol intake and symptom manifestation.
  • Symptoms included vomiting, diarrhea, pruritus, skin rashes, facial edema, dyspnea, and hypotension.

Findings:

  • The patient exhibited a marked increase in blood histamine levels.

Related Experiment Videos

  • Complement components C3 and C4 remained within normal ranges during the reaction.
  • These findings suggest a histamine-mediated hypersensitivity reaction to paracetamol.

    • Implications:

    • This case highlights the potential for severe, dose-dependent hypersensitivity reactions to paracetamol.
    • Prompt recognition and management with epinephrine and corticosteroids are effective.
    • Further investigation into the immunological mechanisms of paracetamol hypersensitivity may be warranted.