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Related Experiment Video

Updated: May 13, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

Interleukin 22 polymorphisms and papillary thyroid cancer.

Y G Eun¹, I H Shin, Y C Lee

¹Department of Otolaryngology-Head and Neck Surgery, Kandong Sacred Heart Hospital, Hallym University School of Medicine, 445 Gil-Dong, Kangdong-Gu, Seoul 134-701, South Korea.

Journal of Endocrinological Investigation

|March 2, 2013

Summary

This summary is machine-generated.

The study found that a specific single nucleotide polymorphism (SNP) in the IL22 gene (rs2227485) is associated with an increased risk and multifocality of papillary thyroid cancer (PTC). No significant association was found for the IL22RA1 gene SNP.

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Area of Science:

Genetics and Genomics
Oncology
Immunology

Background:

Interleukin 22 receptor-alpha 1 (IL22RA1) is a class II cytokine receptor involved in pathogen defense and tissue repair.
Genetic polymorphisms in inflammatory cytokines are linked to cancer risk.
Understanding genetic factors in papillary thyroid cancer (PTC) is crucial for risk assessment.

Purpose of the Study:

To investigate the association between single nucleotide polymorphisms (SNPs) in IL22 and IL22RA1 genes and papillary thyroid cancer (PTC).
To determine if these SNPs correlate with clinical parameters of PTC.

Main Methods:

The study included 94 PTC patients and 213 controls.
Direct sequencing was used to analyze one promoter SNP of IL22 (rs2227485) and one SNP of IL22RA1 (rs3795299).
Statistical analysis was performed using specialized genetic analysis software.

Main Results:

The IL22 SNP rs2227485 was significantly associated with an increased risk of PTC.
This SNP also correlated with the number of cancerous lesions (multifocality) in PTC patients.
No significant association was found between the IL22RA1 SNP rs3795299 and PTC risk or clinical parameters.

Conclusions:

The rs2227485 SNP in the IL22 gene may be a risk factor for papillary thyroid cancer.
This genetic variant might also be linked to the multifocality of PTC.
Further research is warranted to elucidate the role of IL22 in thyroid carcinogenesis.