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Updated: May 13, 2026
09:02
Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Veno-occlusive disease following high dose melphalan
Tuphan Kanti Dolai1, K S Nataraj, Maitreyee Bhattacharya
1Department of Hematology, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata, 700014 India.
Summary
Hepatic veno-occlusive disease (VOD) is a rare complication after high-dose therapy (HDT) autologous stem cell transplantation (ASCT) for multiple myeloma (MM). This case highlights the potential for VOD development and fatal outcomes, even in this specific patient population.
Area of Science:
- Hematology
- Transplantation Medicine
- Oncology
Background:
- Hepatic veno-occlusive disease (VOD) is a known complication of hematopoietic stem cell transplantation.
- VOD is considered uncommon following high-dose therapy (HDT) for autologous stem cell transplantation (ASCT) in multiple myeloma (MM) patients.
Purpose of the Study:
- To report a case of VOD developing after HDT for ASCT in a patient with multiple myeloma.
- To emphasize the potential for VOD as a complication in this specific clinical scenario.
Main Methods:
- Case report of a 54-year-old male with multiple myeloma.
- Documented development of VOD on day 16 post-transplant.
- Clinical course and outcome assessment.
Main Results:
- The patient developed VOD on day 16 after HDT for ASCT.
- The patient experienced multi-organ failure.
- The patient ultimately died due to complications.
Conclusions:
- High-dose therapy for autologous stem cell transplantation in multiple myeloma patients can be complicated by hepatic veno-occlusive disease.
- This case underscores the importance of vigilance for VOD even in seemingly low-risk scenarios within MM ASCT.
- Fatal outcomes due to VOD and subsequent multi-organ failure are possible.
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