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Updated: May 13, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

The pathogenesis of dengue.

Sophie Yacoub¹, Juthathip Mongkolsapaya, Gavin Screaton

¹Department of Medicine, Imperial College, Hammersmith Campus, London, UK. s.yacoub@imperial.ac.uk

Current Opinion in Infectious Diseases

|March 2, 2013

Summary

Dengue pathogenesis involves complex interactions between host immunity, genetics, and viral factors. Understanding these mechanisms is key to developing effective treatments and vaccines for this growing global health threat.

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Published on: November 1, 2018

Area of Science:

Virology
Immunology
Epidemiology

Background:

Dengue incidence has surged globally, with no current treatments or vaccines.
Severe dengue pathogenesis is increasingly understood as immune-mediated, particularly in secondary infections.

Purpose of the Study:

To review recent advances in understanding dengue pathogenesis.
To explore host and viral determinants contributing to disease severity.

Main Methods:

Review of recent immunological, genetic, and epidemiological studies.
Analysis of monoclonal antibody data and T-cell responses.
Examination of genome-wide association studies and viral virulence factors.

Main Results:

Evidence highlights neutralizing vs. enhancing monoclonal antibodies and their epitopes, impacting vaccine design.
T-cell immunopathology shows cross-reactive, pro-inflammatory T cells in severe dengue.
Genome-wide association studies identified susceptibility loci; epidemiological studies defined at-risk groups.

Conclusions:

Dengue pathogenesis is a complex interplay of host immunity, genetic predisposition, and viral factors.
Understanding these mechanisms is vital for developing prognostic markers, diagnostics, therapeutics, and a safe vaccine.