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A one-two punch of miR-126/126* against metastasis
1Department of Molecular Biology, LTL255, Washington Road, Princeton University, Princeton, New Jersey 08544, USA.
Nature Cell Biology
|March 2, 2013
Abstract:
MicroRNAs regulate cancer metastasis by modulating both the intrinsic properties of tumour cells and their interactions with the tumour stroma. Both strands of the miR-126/miR-126* duplex are now shown to simultaneously target the Sdf-1α cytokine to reduce the recruitment of mesenchymal stem cells and inflammatory monocytes to primary tumours, thereby inhibiting lung metastasis.
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