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Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 13, 2026

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

Published on: October 6, 2018

New and old technologies for organ replacement.

Jeffrey L Platt¹, Marilia Cascalho

¹Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA. plattjl@umich.edu

Current Opinion in Organ Transplantation

|March 2, 2013

Summary

This summary is machine-generated.

Organ transplantation demand outstrips supply. While stem cell technology shows promise for generating new organs, significant challenges remain in their development and application for future patient needs.

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Last Updated: May 13, 2026

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Area of Science:

Regenerative Medicine
Organ Transplantation
Biotechnology

Background:

The demand for organ transplantation consistently rises, creating a critical gap between available organs and patient needs.
Exploring novel and existing technologies is crucial for addressing the organ shortage crisis.

Purpose of the Study:

To analyze the projected evolution of organ transplantation demand over the coming decades.
To identify and evaluate the potential of new and existing technologies for organ replacement.

Main Methods:

Forecasting organ transplantation demand based on current trends.
Assessing the capabilities of pluripotent stem cells for organogenesis.
Reviewing advancements in regenerative medicine and bioengineering.

Main Results:

Pluripotent stem cells offer theoretical potential for generating sufficient numbers of cells to assemble complex, functional organs.
Significant scientific and technological hurdles persist in reliably directing stem cell differentiation and organ assembly.

Conclusions:

Anticipated dramatic growth in organ replacement needs over the next 2-3 decades necessitates urgent technological advancements.
While scientific progress is expected to overcome generation challenges, societal needs and priorities must guide the application of these new organ technologies.