Related Experiment Video

Updated: May 13, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children

Chang-Duk Ha1, Jin-Kyung Cho1, Taekyung Han1

  • 1Sungkyunkwan University, Suwon, Republic of Korea.

Asia-Pacific Journal of Public Health
|March 2, 2013
PubMed

Insights

The peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) gene Gly482Ser polymorphism is linked to insulin resistance in Korean children. Lifestyle factors like physical activity and body fat may influence these genetic effects.

Area of Science:

  • Genetics and Metabolism
  • Pediatric Endocrinology

Background:

  • Insulin resistance is a growing concern in pediatric populations.
  • Genetic factors, such as PGC-1α gene variants, may play a role in its development.
  • Understanding these associations is crucial for early intervention strategies.

Purpose of the Study:

  • To examine the relationship between the PGC-1α gene Gly482Ser polymorphism (rs8192678) and insulin resistance markers in Korean children.
  • To investigate the influence of lifestyle factors on this genetic association.

Main Methods:

  • A cohort of 286 Korean children (10-12 years old) was studied.
  • Measurements included body fat, blood pressure, lipids, glucose, insulin, HOMA-IR, and physical activity (PA).
  • Statistical analyses were performed to assess genotype-specific differences and the impact of covariates.

Main Results:

  • Significant genotype-specific differences were observed for percentage body fat, insulin levels, and HOMA-IR (P < .05).
  • These differences were notably reduced after adjusting for age, sex, Tanner stage, body fat, and PA.
  • No significant genotype differences were found for other measured variables.

Conclusions:

  • The PGC-1α Gly482Ser polymorphism is associated with insulin resistance parameters in Korean children.
  • Lifestyle factors, particularly physical activity and body fat, appear to modulate the genetic influence on insulin resistance.
  • These findings highlight the interplay between genetics and environment in pediatric metabolic health.

Keywords:
PGC-1α genebody fatnesschildreninsulin resistancephysical activity

More Related Videos

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice11:10

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

Published on: November 16, 2011

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...