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Updated: May 13, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Variation of HIV-1 mutation spectra among cell types
Colleen M Holtz1, Louis M Mansky
1Institute for Molecular Virology, Department of Diagnostic and Biological Sciences, MinnCResT Program, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA.
Abstract:
The high rates of mutation, recombination, and replication drive HIV-1 diversity. In this study, we investigated how cell type affects viral mutation rate and mutation spectra. In studying four different cell types, no differences in mutation rate were observed, but intriguingly cell type differences impacted HIV-1 mutation spectra. This is the first description of significant differences in HIV-1 mutation spectra observed in different cell types in the absence of changes in the viral mutation rate.
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