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Allergic Reactions: Anaphylaxis

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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...

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Related Experiment Video

Updated: May 13, 2026

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film

Published on: December 13, 2024

Anaphylaxis to topically applied sodium fusidate.

Mi-Ran Park¹, Do-Soo Kim, Jihyun Kim

¹Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ; Environmental Health Center for Atopic Diseases, Samsung Medical Center, Seoul, Korea.

Allergy, Asthma & Immunology Research

|March 2, 2013

Summary

This study reports the first case of anaphylaxis caused by topical fusidic acid applied to abrasions. This severe allergic reaction highlights a previously undocumented risk of this common antibiotic treatment.

Keywords:

Anaphylaxis fusidic acid ointment

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Published on: September 27, 2017

Area of Science:

Dermatology
Allergology
Pharmacology

Background:

Fusidic acid is a topical antibiotic effective against gram-positive bacteria.
Allergic reactions like contact dermatitis are known side effects.
Anaphylaxis from topical fusidic acid has not been previously documented.

Purpose of the Study:

To document the first case of anaphylaxis following topical fusidic acid application to abrasions.
To investigate the causal link between topical fusidic acid and anaphylaxis.

Main Methods:

A 16-year-old male experienced anaphylaxis after topical fusidic acid treatment for abrasions.
Oral provocation with sodium fusidate confirmed the allergic reaction.
Pulmonary function tests (FEV1) were monitored during the challenge.

Main Results:

The patient developed urticaria, eyelid swelling, cough, and respiratory distress.
Oral provocation led to throat itching, chest discomfort, and urticaria.
Forced expiratory volume in 1 second (FEV1) significantly decreased during the challenge.

Conclusions:

Topical fusidic acid applied to abrasions can cause anaphylaxis.
This case represents a novel and severe adverse reaction to fusidic acid.
Caution is advised when using fusidic acid on compromised skin barriers.