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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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Measurement of Tumor T2* Relaxation Times after Iron Oxide Nanoparticle Administration
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Published on: May 19, 2023

[Iron quantification in iron overload disease using MRI].

B P Schönnagel1, R Fischer, P Nielsen

  • 1Klinik und Poliklinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg. b.schoennagel@uke.de

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|March 2, 2013
PubMed
Summary
This summary is machine-generated.

Iron deficiency anemia affects 30% globally, while hereditary hemochromatosis is a common genetic disorder. Accurately diagnosing iron overload is crucial for patient prognosis and requires improved noninvasive assessment methods.

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Area of Science:

  • Biochemistry
  • Human Physiology
  • Genetics

Context:

  • Iron is an essential nutrient vital for numerous metabolic processes.
  • Iron deficiency anemia affects approximately 30% of the global population.
  • Hereditary hemochromatosis is the most prevalent monogenic inherited disease, particularly in populations like Germany.

Purpose:

  • To highlight the diagnostic challenges in quantifying organ iron overload.
  • To emphasize the clinical significance of body and organ iron concentration for prognosis.
  • To underscore the need for a quantitative, noninvasive, safe, and accurate method for assessing body iron stores, as identified by a 2001 NIDDK workshop.

Summary:

  • While iron deficiency anemia is manageable, diagnosing and quantifying iron overload presents significant clinical challenges.
  • Accurate assessment of iron levels in organs is critical for predicting outcomes in iron overload diseases.
  • Existing diagnostic methods for iron overload lack the desired accuracy, safety, and noninvasiveness.

Impact:

  • Improved diagnostic tools for iron overload can lead to better patient management and outcomes.
  • Noninvasive assessment of iron storage will aid in early detection and intervention strategies.
  • Addressing the need for accurate iron quantification can reduce the clinical burden of iron overload diseases.