Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NCCN guideline concordance in colon and rectal cancer patients within a comprehensive health system.

American journal of surgery·2024
Same author

It's not lack of evidence holding back resect and discard.

Gastrointestinal endoscopy·2022
Same author

Variability in adenoma detection rate in control groups of randomized colonoscopy trials: a systematic review and meta-analysis.

Gastrointestinal endoscopy·2022
Same author

Impact of withdrawal time on adenoma detection rate: results from a prospective multicenter trial.

Gastrointestinal endoscopy·2022
Same author

Everted diverticula with endoscopic mucosal changes mimicking serrated lesions (with video).

Gastrointestinal endoscopy·2022
Same author

Impact of Artificial Intelligence on Colonoscopy Surveillance After Polyp Removal: A Pooled Analysis of Randomized Trials.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2022
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

Elevated phospholipase A2 activities in plasma samples from multiple cancers.

Hui Cai1, Elena G Chiorean, Michael V Chiorean

  • 1Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

Plos One
|March 2, 2013
PubMed
Summary
This summary is machine-generated.

Elevated phospholipase A2 (PLA2) enzyme activities were detected in plasma from patients with colorectal, lung, pancreatic, and bladder cancers. This finding suggests PLA2s as potential biomarkers for early cancer detection.

More Related Videos

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2
10:31

A Liposome Membrane Permeability Assay for Investigating the Effects of Phosphatidylinositol Phosphate Groups on Membranotropic Action of Venom PLA2

Published on: September 26, 2025

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma
05:44

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Area of Science:

  • Biochemistry and Molecular Biology
  • Oncology
  • Clinical Diagnostics

Background:

  • Phospholipase A2 (PLA2) enzymes are increasingly recognized for their roles in cancer development and progression.
  • Previous research has not extensively explored plasma PLA2 activity as a diagnostic marker across multiple cancer types.

Purpose of the Study:

  • To investigate and report the first detection of elevated phospholipase A2 (PLA2) activities in plasma from patients diagnosed with various cancers.
  • To assess the potential of plasma PLA2 activity as a diagnostic biomarker for colorectal, lung, pancreatic, and bladder cancers.

Main Methods:

  • Analysis of plasma samples from two independent cohorts of cancer patients and healthy controls.
  • Quantification of total and subtype-specific PLA2 activities using a validated quantitative fluorescent assay.
  • Subtype PLA2 activities were determined using selective inhibitors.

Main Results:

  • Significantly elevated total and subtype PLA2 activities were observed in plasma from patients with colorectal, lung, pancreatic, and bladder cancers compared to healthy controls.
  • PLA2 activities were higher in late-stage versus early-stage colorectal cancer.
  • Plasma PLA2 activities demonstrated approximately 70% sensitivity and specificity for cancer detection, independent of factors like sex, smoking, alcohol consumption, or BMI.

Conclusions:

  • Plasma phospholipase A2 (PLA2) activity is a promising pan-cancer biomarker.
  • Elevated PLA2 levels represent a potential diagnostic marker for early detection of colorectal, lung, pancreatic, and bladder cancers.
  • Further research is warranted to explore the full clinical utility of PLA2 activity as a cancer marker and therapeutic target.