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Updated: May 13, 2026
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Headache after exposure to 'date-rape' drugs.
Richard Peatfield1, Carlos M Villalón
1Princess Margaret Migraine Clinic, Charing Cross Hospital, London, W6 8RF UK.
Springerplus
|March 2, 2013
Summary
Two patients experienced prolonged headaches, possibly due to scopolamine exposure from a spiked drink. This may have triggered trigeminal neuropeptide release, causing the severe headaches.
Area of Science:
- Neurology
- Toxicology
Background:
- Headaches can be debilitating and have various causes.
- Unexplained headaches following potential substance ingestion warrant investigation.
Purpose of the Study:
- To investigate the potential cause of prolonged, featureless headaches in two patients.
- To explore the link between suspected scopolamine exposure and headache pathophysiology.
Main Methods:
- Case report of two patients presenting with similar prolonged headache symptoms.
- Clinical assessment and speculative etiological analysis based on patient history.
Main Results:
- Both patients reported a prolonged, featureless headache after suspecting their drinks were spiked.
- Scopolamine exposure is hypothesized as the causative agent.
Conclusions:
- Scopolamine exposure may lead to prolonged headaches through enhanced trigeminal release of vasodilator neuropeptides like CGRP.
- This case highlights a potential, albeit rare, cause of severe headache following suspected substance exposure.
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