Related Experiment Video
Updated: May 13, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
[Study on prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex]
Xiao-yu Xuan1, Ya-jing Wang, Hui Tian
1Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China. zijimei369@126.com
Objective:
To study formulation of self-microemulsifying drug delivery system (SMEDDS) of mangiferin phospholipid complex and improve dissolution and bioavailability of mangiferin.
Methods:
Ternary phase diagram was applied to optimize the prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex, and the best recipe was selected by comprehensive evaluation of the speed of microemulsifying, microemulsion size and electric potential.
Results:
The optimum formulation of SMEDDS was composed of IPM-Cremphor EL35-labrasol = 2 : 4.8 : 3.2.
Conclusion:
Self-microemulsifying drug delivery system of mangiferin phospholipid complex can effectively improve the dissolution of Mangiferin.
Related Concept Videos
Modified-Release Drug Delivery Systems: Influencing Factors
Modified-Release Drug Delivery Systems: Site-Targeted
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Bioavailability Enhancement: Drug Solubility Enhancement
Oral Drug Delivery Systems: Delayed-Release Systems
Bioavailability Enhancement: Drug Permeability Enhancement
