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Related Concept Videos

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Optical Trapping of Nanoparticles
13:39

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Published on: January 15, 2013

Nanobiodevices for biomolecule analysis and imaging.

Takao Yasui1, Noritada Kaji, Yoshinobu Baba

  • 1Department of Applied Chemistry, Graduate School of Engineering, FIRST Research Center for Innovative Nanobiodevices, Nagoya University, Nagoya 464-8603, Japan. yasui@apchem.nagoya-u.ac.jp

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|March 5, 2013
PubMed
Summary

Nanobiodevices offer significant advantages in analyzing biomolecules and cells for disease diagnostics, imaging, and drug delivery. This review covers their fabrication and diverse applications in medicine.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Molecular Biology

Background:

  • Nanobiodevices integrate nanoscale materials with biological systems for advanced analysis.
  • They are crucial for applications in disease diagnostics, molecular imaging, regenerative medicine, and drug delivery.

Purpose of the Study:

  • To review nanobiodevices for biomedical applications.
  • To discuss fabrication technologies and advantages of nanobiodevices.
  • To highlight diverse applications in diagnostics, imaging, and therapeutics.

Main Methods:

  • Review of top-down nanofabrication and bottom-up molecular self-assembly.
  • Discussion of nanopillar/nanowall arrays for ultrafast molecule separation.
  • Exploration of functionalized carbon nanotubes and quantum dots for specific applications.

Main Results:

  • Nanobiodevices enable ultrafast separation of DNA and proteins using nanopillar/nanowall arrays.
  • Functionalized carbon nanotubes provide subcellular localization information.
  • Quantum dots show promise in RNA screening, protein detection, and cancer diagnostics/therapeutics.

Conclusions:

  • Nanobiodevices present numerous advantages for biological, medical, and clinical applications.
  • Advanced fabrication techniques facilitate the development of sophisticated nanobiodevices.
  • Emerging applications of nanobiodevices include sensitive disease detection and targeted cancer therapies.