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Updated: Aug 11, 2026

Whole-Kidney Three-Dimensional Staining with CUBIC
Published on: July 18, 2022
Renal morphologic lesions reminiscent of diabetic nephropathy
Kirtee Raparia1, Irtaza Usman, Yashpal S Kanwar
1Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA.
Context:
Nodular, intercapillary glomerulosclerotic lesions resembling Kimmelstiel-Wilson nodules commonly observed in diabetic nephropathy can also be seen in patients without any clinical history or evidence of diabetes.
Objectives:
To discuss the pathobiology of lesions reminiscent of diabetes nephropathy, including light-chain deposition disease, amyloidosis, immunotactoid nephropathy, the membranoproliferative form of glomerulonephritis, and idiopathic nodular glomerulosclerosis, and how to differentiate them from diabetic nephropathy.
Data Sources:
Published literature and authors' personal experience.
Conclusions:
The well-formed, intercapillary, nodular mesangial lesions, along with thickened glomerular basement membranes and tubular basement membranes, and hyaline arteriolosclerosis are virtually pathognomic of diabetic nephropathy. However, the pathologist must exclude lesions reminiscent of diabetic nephropathy by performing special stains on histologic sections, immunofluorescence, and electron microscopic studies.
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