Solid lipid nanoparticles induced hematological changes and inflammatory response in mice.

Area of Science:

• Nanotechnology
• Pharmacology
• Toxicology

Background:

• Solid lipid nanoparticles (SLNs) represent an advanced drug delivery system with potential for targeted therapies.
• Despite their promise, the in vivo toxicity of SLNs has not been thoroughly investigated.

Purpose of the Study:

• To evaluate the in vivo toxicity of two types of solid lipid nanoparticles (SLNs) after a 10-day exposure in mice.
• To assess the safety profile of triestearin-based SLNs (TN) and natural wax-based SLNs (VN) for potential therapeutic applications.

Main Methods:

• Mice were administered TN, VN, or vehicle intraperitoneally for 10 days.
• Post-treatment, necropsies, histopathological examinations, hematological analysis, and assessments of hepatic and renal functions were conducted.

Main Results:

• Both TN and VN were absorbed and induced an inflammatory response in adipose tissue.
• Histopathological analysis revealed no toxicity in either SLN-treated group.
• Body weights remained consistent, and serum biochemical parameters showed low toxicity.

Conclusions:

• These findings suggest that triestearin-based and natural wax-based SLNs exhibit a low toxicity profile in short-term in vivo exposure.
• Further investigation into the observed inflammatory response is recommended to establish the long-term safety of these SLNs for drug delivery.