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Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

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Related Experiment Video

Updated: May 13, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
05:31

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Placenta-derived microparticles.

Anat Aharon1, Benjamin Brenner

  • 1Thrombosis & Hemostasis Unit, Rambam Health Care Campus and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology Haifa, Israel. a_aharon@rambam.health.gov.il

Thrombosis Research
|March 5, 2013
PubMed
Summary
This summary is machine-generated.

Microparticles (MPs), small vesicles, are crucial in pregnancy. This review explores their role in normal pregnancies and gestational vascular complications (GVC), highlighting their impact on placental health and disease.

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Area of Science:

  • Obstetrics and Gynecology
  • Vascular Biology
  • Cellular Biology

Background:

  • Microparticles (MPs) are sub-micron membrane vesicles involved in intercellular communication.
  • MPs play a role in both normal pregnancy and gestational vascular complications (GVC).

Purpose of the Study:

  • To review the multifaceted effects of MPs on placental physiology.
  • To examine the involvement of MPs in pathological states leading to GVC.

Main Methods:

  • Literature review of studies on microparticles in pregnancy.
  • Analysis of MP functions in placental hemostasis, trophoblast migration, invasion, and vasculature.
  • Investigation of MP roles in thrombosis, inflammation, and endothelial dysfunction.

Main Results:

  • MPs influence key placental processes like hemostasis and trophoblast dynamics.
  • MPs are implicated in the pathophysiology of GVC through thrombosis, inflammation, and endothelial dysfunction.

Conclusions:

  • MPs are critical mediators of placental crosstalk in normal and complicated pregnancies.
  • Understanding MP function is vital for diagnosing and managing GVC.