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Updated: May 13, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

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Published on: November 29, 2024

Antiphospholipid syndrome: looking for a refocusing.

Jean-Christophe Gris1, Sylvie Bouvier

  • 1Department of Haematology, University Hospital, Nîmes and University of Montpellier, France. jean.christophe.gris@chu-nimes.fr

Thrombosis Research
|March 5, 2013
PubMed
Summary
This summary is machine-generated.

Antiphospholipid syndrome (APS) diagnosis needs refinement. Current criteria for antiphospholipid antibodies (aPL) and associated symptoms, especially in obstetrics, are variable, leading to over-diagnosis. Revising APS definitions will improve diagnostic accuracy and enable precision medicine.

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Last Updated: May 13, 2026

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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions
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PIP-on-a-chip: A Label-free Study of Protein-phosphoinositide Interactions

Published on: July 27, 2017

Area of Science:

  • Immunology
  • Rheumatology
  • Obstetrics

Background:

  • Antiphospholipid syndrome (APS) involves thrombotic or obstetric events linked to antiphospholipid antibodies (aPL).
  • Current aPL testing standardization faces challenges due to evolving understanding of APS pathophysiology.
  • Epidemiological associations between symptoms and aPLs show high variability, risking over-diagnosis, particularly in obstetrics.

Purpose of the Study:

  • To review and propose a revised definition for Antiphospholipid Syndrome (APS).
  • To address the limitations of current diagnostic criteria, including molecularly unclassified syndromes and non-specific markers.
  • To advocate for a move towards precision medicine in APS diagnosis and management.

Main Methods:

  • Literature review of APS definition and pathophysiology.
  • Analysis of current diagnostic criteria for APS and aPL testing.
  • Evaluation of epidemiological evidence linking aPLs to clinical manifestations.

Main Results:

  • Current APS diagnostic criteria exhibit variable sensitivity and specificity.
  • Equivocal evidence, especially in obstetrical presentations, contributes to potential over-diagnosis.
  • Molecularly unclassified syndromes and non-specific markers complicate accurate diagnosis.

Conclusions:

  • The current definition of APS requires revision based on biological mechanisms.
  • Abandoning unclassified clinical syndromes and non-specific markers is proposed.
  • Narrowing APS criteria is essential for advancing towards precision medicine in APS.