Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rheumatic Heart Disease I: Introduction

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

Regulation of the Unfolded Protein Response

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...

Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.

Aging cell·2026

Same author

Identification and Evaluation of Conserved Subunit Vaccine Candidates Conferring Cross-Serotype Protection Against <i>Streptococcus suis</i> Serotypes 2, 7, 8, and 9.

Transboundary and emerging diseases·2026

Same author

RIVER delivers multimodal gene-directed regulatory interactions across diverse biological contexts with broad application potentials.

Science China. Life sciences·2026

Same author

A dual-functional nanoplatform based on pH-driven self-assembly of pea protein isolate-folic acid conjugate for targeted and stabilized delivery of curcumin.

Food research international (Ottawa, Ont.)·2026

Same author

DenseDuckMOT: A Real-Time Detection-Tracking Coupled Counting Framework for Complex Avicultural Environments.

Animals : an open access journal from MDPI·2026

Same author

Toward Generalizable Data-Driven Pharmacokinetics with Interpretable Neural ODEs.

Journal of chemical information and modeling·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

ERAP1 and ankylosing spondylitis.

Sarah Keidel¹, Liye Chen, Jennifer Pointon

¹University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Nuffield Orthopaedic Centre, Windmill Road, Oxford OX3 7LD, UK.

Current Opinion in Immunology

|March 5, 2013

Summary

This summary is machine-generated.

Endoplasmic reticulum aminopeptidase 1 (ERAP1) strongly associates with ankylosing spondylitis (AS) in HLA-B27 positive individuals. ERAP1 variants with reduced activity may be protective, suggesting ERAP1 inhibition as a potential AS treatment.

More Related Videos

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 13, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Anti-Nuclear Antibody Screening Using HEp-2 Cells

Published on: June 23, 2014

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

Immunogenetics
Molecular Biology
Rheumatology

Background:

Ankylosing spondylitis (AS) shows a strong genetic link with ERAP1, particularly in HLA-B27 positive patients.
ERAP1 plays a crucial role in peptide processing for HLA class I molecules, impacting HLA-B27 stability and presentation.
The pathogenic mechanism of ERAP1 in AS may involve innate immunity, including interactions with KIR receptors and the unfolded protein response.

Purpose of the Study:

To investigate the pathogenetic implications of ERAP1 in ankylosing spondylitis.
To explore the role of ERAP1 in HLA-B27 processing and immune system interactions.
To evaluate the potential of ERAP1 as a therapeutic target for AS.

Main Methods:

Genetic association studies analyzing ERAP1 variants in AS cohorts.
Functional assays assessing ERAP1's effect on peptide trimming and HLA-B27 binding.
In vitro studies examining ERAP1's influence on innate immune cell interactions and ER stress pathways.

Main Results:

Specific ERAP1 variants are genetically associated with AS susceptibility in an HLA-B27 dependent manner.
ERAP1 activity influences the peptide repertoire presented by HLA-B27, potentially affecting adaptive and autoimmune responses.
Reduced ERAP1 endopeptidase activity correlates with protection against AS, suggesting a role in innate immune modulation.

Conclusions:

ERAP1 is a key genetic factor in AS pathogenesis, with effects potentially mediated through innate immunity.
ERAP1's role in HLA-B27 processing and immune receptor interactions is critical in AS.
Targeting ERAP1 activity, possibly through inhibition, presents a promising future therapeutic strategy for ankylosing spondylitis.