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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

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Related Experiment Video

Updated: May 13, 2026

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model
06:59

Trabecular Bone Microarchitecture Evaluation in an Osteoporosis Mouse Model

Published on: September 8, 2023

Clinical factors associated with trabecular bone score.

William D Leslie1, Marc-Antoine Krieg2, Didier Hans2

  • 1Department of Medicine, University of Manitoba, Winnipeg, MB, Canada; Department of Radiology, University of Manitoba, Winnipeg, MB, Canada.

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|March 5, 2013
PubMed
Summary

Trabecular bone score (TBS), a texture analysis of DXA scans, identifies osteoporosis risk factors beyond bone mineral density (BMD). Reduced TBS is linked to factors like glucocorticoid use and prior fractures, offering new insights into fracture prediction.

Keywords:
Bone mineral densityosteoporosispostmenopausal womentrabecular bone score

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Area of Science:

  • Osteoporosis research
  • Bone health assessment
  • Medical imaging analysis

Background:

  • Dual-energy X-ray absorptiometry (DXA) measures bone mineral density (BMD), the standard for osteoporosis diagnosis.
  • BMD alone does not fully capture bone microarchitecture deterioration, a key factor in fracture risk.
  • Trabecular Bone Score (TBS) is a novel texture analysis from DXA images that assesses bone microarchitecture and predicts fractures independently of BMD.

Purpose of the Study:

  • To identify clinical factors associated with baseline lumbar spine Trabecular Bone Score (TBS).
  • To evaluate the relationship between TBS and established osteoporosis risk factors.
  • To determine if TBS provides information independent of BMD in assessing fracture risk.

Main Methods:

  • Analysis of baseline DXA scans from 29,407 women aged 50 years or older in Manitoba, Canada.
  • Lumbar spine TBS was calculated from DXA images, blinded to clinical data.
  • Statistical analysis using multiple linear regression and logistic regression to assess associations between TBS and clinical factors.

Main Results:

  • Bone mineral density (BMD) explained only a small portion (7-11%) of the variance in TBS.
  • Reduced lumbar spine TBS was significantly associated with recent glucocorticoid use, prior major fracture, rheumatoid arthritis, COPD, high alcohol intake, and higher BMI.
  • Recent osteoporosis therapy was associated with a lower likelihood of reduced TBS, even after adjusting for BMD.

Conclusions:

  • Lumbar spine TBS is strongly associated with numerous clinical risk factors for osteoporotic fractures.
  • TBS captures microarchitectural bone changes that are relevant to fracture risk, independent of BMD.
  • Further research is needed to ascertain if TBS can enhance or replace current clinical risk factors in fracture prediction models.