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Littoral cell angiosarcoma in a dog.

A Gal¹, J Yamate, H M Golbar

¹University of Illinois, College of Veterinary Medicine, Department of Pathobiology, Urbana, IL 61802, USA. agal2@illinois.edu

Journal of Comparative Pathology

|March 5, 2013

Summary

This summary is machine-generated.

This study details a rare canine splenic tumor, littoral cell angiosarcoma, in a beagle. The cancer cells showed mixed endothelial and histiocytic markers and spread rapidly, leading to the dog's death.

Keywords:

dog immunohistochemistry littoral cell angiosarcoma spleen

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Area of Science:

Veterinary Pathology
Canine Oncology
Tumor Biology

Background:

Littoral cell angiosarcoma is a rare vascular tumor originating from the spleen.
Understanding its characteristics is crucial for diagnosis and treatment in veterinary medicine.

Observation:

A 12-year-old female beagle presented with a splenic mass.
The tumor exhibited anastomosing microvascular channels and papillary fronds histologically.

Findings:

Neoplastic cells expressed both endothelial (CD34) and histiocytic markers.
Cells were erythrophagocytic, indicating phagocytosis of red blood cells.
High Ki67 proliferation index suggested malignancy.

Implications:

This case highlights the aggressive nature of canine littoral cell angiosarcoma.
Immunohistochemical markers aid in differentiating this tumor from other splenic neoplasms.
Further research into canine vascular tumors is warranted.