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Updated: May 13, 2026
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
Factors affecting local progression after percutaneous cryoablation of lung tumors
Hideki Yashiro1, Seishi Nakatsuka, Masanori Inoue
1Department of Diagnostic Radiology, School of Medicine, Keio University, Tokyo, Japan. yashiro@rad.med.keio.ac.jp
Purpose:
To evaluate factors predicting local tumor progression after percutaneous cryoablation of lung tumors (PCLT).
Materials And Methods:
Seventy-one consecutive patients with 210 tumors (11 primary and 199 metastatic pulmonary neoplasms; mean maximum diameter, 12.8 mm) were treated with 102 sessions of PCLT. Rates of local tumor progression and technique effectiveness were estimated by Kaplan-Meier method. Multiple variables were evaluated with the log-rank test, followed by uni- and multivariate multilevel analyses to identify independent risk factors, and hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. All statistical tests were two-sided.
Results:
Median follow-up period was 454 days (range, 79-2,467 d). Local tumor progression occurred in 50 tumors (23.8%). One-, 2-, and 3-year local progression-free rates were 80.4%, 69.0%, and 67.7%, respectively, and technique effectiveness rates were 91.4%, 83.0%, and 83.0%, respectively. Existence of a thick vessel (diameter≥3 mm) no more than 3 mm from the edge of the tumor was assessed as an independent factor (HR, 3.84; 95% CI, 1.59-9.30; P = .003) associated with local progression by multivariate analysis.
Conclusions:
Presence of a vessel at least 3 mm in diameter close to the tumor represents an independent risk factor for local progression after PCLT.