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Published on: February 9, 2011
[Multifocal osteoarticular infection caused by Salmonella non typhi in a child with sickle cell disease]
Insights
Children with sickle cell disease are vulnerable to severe Salmonella infections, leading to bone and joint complications. Prompt recognition and intensive care are crucial for managing these serious infections.
Area of Science:
- Pediatrics
- Infectious Diseases
- Hematology
Background:
- Sickle cell disease is a common monogenic hereditary hemoglobinopathy.
- It is characterized by vaso-occlusive crises, hemolytic anemia, and susceptibility to severe infections.
- Salmonella non typhi infections pose a significant risk to these patients.
Observation:
- A 2-year-old child with SCD developed severe sepsis from Salmonella non typhi.
- The infection led to multifocal osteomyelitis and arthritis, proving difficult to manage.
- Treatment complications included cardiorespiratory arrest, neurological damage, and nosocomial infections.
Findings:
- Salmonella non typhi can cause severe osseous and articular infections in children with SCD.
- Prompt recognition and management of these infections are critical.
- This case highlights the multifocal nature and severity of Salmonella infections in SCD.
Implications:
- Patients with SCD require vigilant monitoring for infections.
- Urgent and intensive care is essential for managing severe infections in SCD.
- Understanding infection risks is vital for improving outcomes in pediatric SCD.
Introduction:
Sickle cell disease is the most common monogenic hereditary hemoglobinopathy. Its course is marked by vaso-occlusive crises (VOC), episodes of acute hemolytic anemia on a background of chronic hemolytic anemia, and severe infections.
Case Report:
A 2-year-old child with sickle cell disease presented with severe sepsis caused by Salmonella non typhi. Control of the sepsis was difficult, with multifocal osteomyelitis and arthritis, which required prolonged intravenous antibiotic therapy. Prolonged treatment was complicated by cardiorespiratory arrest and severe neurological damage, as well as nosocomial infections.
Conclusion:
Osseous articular infections caused by Salmonella non typhi are a common complication in children with sickle cell disease, which need to be promptly recognized. Management remains a great concern. The clinical case reported herein is original in its multifocal evolution. It illustrates the vulnerability of patients with sickle cell disease and the need for urgent and intensive care in the case of infection.
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