Related Experiment Video
Updated: May 13, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Regulated unfolding of proteins in signaling
Diana M Mitrea1, Richard W Kriwacki
1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Abstract:
The transduction of biological signals often involves structural rearrangements of proteins in response to input signals, which leads to functional outputs. This review discusses the role of regulated partial and complete protein unfolding as a mechanism of controlling protein function and the prevalence of this regulatory mechanism in signal transduction pathways. The principles of regulated unfolding, the stimuli that trigger unfolding, and the coupling of unfolding with other well characterized regulatory mechanism are discussed.
Related Concept Videos
The Unfolded Protein Response
Regulation of the Unfolded Protein Response
Amplifying Signals via Enzymatic Cascade
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Intracellular Signaling Cascades
Intracellular Signaling Cascades
