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Quantification of histone modifications using ¹⁵N metabolic labeling

Chunchao Zhang1, Yifan Liu, Philip C Andrews

  • 1Department of Computational Medicine and Bioinformatics, University of Michigan, USA.

Methods (San Diego, Calif.)
|March 5, 2013
PubMed

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Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...