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Updated: May 13, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
Published on: October 7, 2025
miRNAs: their discovery, biogenesis and mechanism of action
1Department of Clinical Biochemistry, Maisonneuve-Rosemont Hospital, 5415 Boulevard de l'Assomption, Montréal, Québec, H1T 2M4, Canada. nicolas.tetreault@gmail.com
Abstract:
The field of miRNA research is evolving at a very fast pace. Since their discovery almost 20years ago, miRNAs have proven to be of tremendous importance to normal physiological homeostasis as well as to the pathogenesis of major diseases such as cancer. Recent advances describe a key contribution for miRNAs in a wide variety of cellular processes ranging from embryonic development, cell proliferation and apoptosis to prominent roles in disease progression. miRNAs are now of central interest to biomedical research. Here we provide an overview of their discovery, biogenesis and mechanism of action.
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