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Effects of lurasidone on executive function in common marmosets
Takeshi Murai1, Tomokazu Nakako, Masaru Ikejiri
1Drug Research Ikeda Laboratory, Dainippon Sumitomo Pharma Co. Ltd., 33-94 Enoki-cho, Suita, Osaka, Japan.
Behavioural Brain Research
|March 5, 2013
Summary
Lurasidone, an antipsychotic, improved executive function in marmosets, unlike other tested drugs. This suggests lurasidone may be more effective for schizophrenia cognitive impairment.
Area of Science:
- Neuroscience
- Psychopharmacology
- Primate Cognition
Background:
- Cognitive impairment is a key symptom of schizophrenia, often linked to prefrontal cortex dysfunction.
- Lurasidone shows promise in animal models for cognitive deficits, but primate studies were lacking.
Purpose of the Study:
- To evaluate lurasidone's effect on executive function in common marmosets.
- To compare lurasidone's cognitive effects against other antipsychotics in a primate model.
Main Methods:
- Executive function was assessed using the object retrieval with detours (ORD) task in naïve marmosets.
- The effects of lurasidone, haloperidol, olanzapine, risperidone, quetiapine, and clozapine were evaluated.
Main Results:
- Haloperidol, olanzapine, and risperidone impaired performance on easy trials.
- All tested antipsychotics except lurasidone worsened performance on difficult executive function trials.
- Lurasidone dose-dependently improved success rates in difficult trials, showing a significant effect at 10mg/kg.
Conclusions:
- Lurasidone enhances executive function in common marmosets, unlike conventional antipsychotics.
- These findings indicate lurasidone's potential superiority for treating schizophrenia-related cognitive impairment.
