Related Experiment Video
Updated: May 13, 2026

Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
Published on: September 19, 2025
Asthma and influenza virus infection:focusing on cell death and stress pathways in influenza virus replication
Behzad Yeganeh1, Adel Rezaei Moghadam, Ahn Thuy Tran
1Department of Physiology, University of Manitoba, Winnipeg, Canada. Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada. saeid.ghavami@gmail.com, and kcoombs@cc.umanitoba.ca.
Abstract:
Asthma is one of the fastest growing syndromes in many countries and is adding a huge cost to the health care system. Increasing reports have linked airway infectious diseases to asthma. Influenza is one of the most serious airway infectious diseases and in recent years there have been some serious influenza virus pandemics which caused increased fatality in numerous different populations. Diverse host response pathways during virus infection have been identified, including different cell death and survival pathways. These pathways include 1) programmed cell death I (apoptosis), 2) programmed cell death II (autophagy), and 3) endoplasmic reticulum stress with subsequent unfolded protein response (UPR). There has been extensive research on the regulatory roles of these pathways during the influenza virus life cycle. These studies address the benefits of enhancing or inhibiting these pathways on viral replication. Here we review the most recent and significant knowledge in this area for possible benefits to clinicians and basic scientist researchers in different areas of the respiratory and virology sciences.
Related Concept Videos
Influenza
Leaky Scanning
The Extrinsic Apoptotic Pathway
Inhibitors of Viral Protein Synthesis
Overview of Cell Death
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Asthma I: Introduction

