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Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
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Related Experiment Video

Updated: May 13, 2026

Deep Vein Thrombosis Induced by Stasis in Mice Monitored by High Frequency Ultrasonography
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Thrombus formation using endovenous lasers: an in vitro experiment.

T Hennings1, D Hennings, C Lindsay

  • 1Colorado State University, Fort Collins, Colorado 80521.

Phlebology
|March 5, 2013
PubMed
Summary

Pulsed lasers with high-peak power densities create less coagulum during endovenous laser ablation, potentially minimizing thrombus formation. Fibre types did not significantly impact coagulum, but modified fibres did not eliminate it.

Keywords:
chronic venous insufficiencydeep vein thrombosisendovenous laser treatmentpulmonary embolismsaphenofemoral junction

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Area of Science:

  • Vascular Surgery
  • Biomedical Engineering
  • Laser Medicine

Background:

  • Endovenous laser ablation (EVLA) is a common treatment for varicose veins.
  • Thrombus formation is a potential complication of EVLA.
  • Optimizing laser parameters and equipment is crucial for improving EVLA outcomes.

Purpose of the Study:

  • To simulate thrombus formation during EVLA.
  • To measure coagulum formation using in vitro laser exposures in porcine blood.
  • To investigate the influence of laser types, power densities, and fiber specifications on thrombus formation.

Main Methods:

  • Tested continuous wave (CW) lasers (810, 940, 980, 1310, 1470 nm) and microsecond pulsed wave (PW) lasers (1064 nm Nd:YAG, 1320 nm Nd:YAG, 2100 nm THC:YAG).
  • Utilized standard fibers (365, 550, 600 μm) and prototype modified tip fibers.
  • Measured coagulum formation in porcine blood under various laser exposures.

Main Results:

  • Pulsed lasers with high-peak power densities resulted in significantly less coagulum formation.
  • Standard fiber specifications (diameter) did not influence coagulum formation.
  • Prototype modified tip fibers, designed to minimize contact with the vein wall, did not eliminate coagulum formation.

Conclusions:

  • Microsecond-pulsed wave lasers with high-peak power densities may be preferable for minimizing soft thrombus formation in EVLA.
  • Further research into laser parameters and fiber designs is warranted to optimize EVLA safety and efficacy.
  • Understanding coagulum formation is key to reducing complications associated with endovenous laser treatments.